The Enigma of Rapamycin Dosage
نویسندگان
چکیده
منابع مشابه
The Enigma of Rapamycin Dosage.
The mTOR pathway is a critical regulator of cell growth, proliferation, metabolism, and survival. Dysregulation of mTOR signaling has been observed in most cancers and, thus, the mTOR pathway has been extensively studied for therapeutic intervention. Rapamycin is a natural product that inhibits mTOR with high specificity. However, its efficacy varies by dose in several contexts. First, differen...
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ژورنال
عنوان ژورنال: Molecular Cancer Therapeutics
سال: 2016
ISSN: 1535-7163,1538-8514
DOI: 10.1158/1535-7163.mct-15-0720